Evaluation of the antibody levels against bcg and polysaccharides meningococcal vaccines when combined, co-administrated or administrated at different intervals in murine model

Anotace: Bacillus Calmette-Guerin (BCG) and polysaccharide meningococcal (pMen) vaccines are required to travel to some countries, medical staff to deal with disease carriers, and for special cases as well. However, there were not enough studies on the immunogenic intervention between them when given together or in combination. Hence, we tried to assess the antibody-mediated immune response in groups of mice when different BCG vaccines and pMen were combined or given together, either concurrently or with a 14-day break between them. The antibody titer was measured in each group after 21 and 42 days from the first injection. Our results showed that it was safe and effective to give these two vaccines combined or simultaneously. Moreover, they exhibited a potent synergistic effect even if there was a 14 days gap between their administration. However, more research is needed to investigate the immunological intervention's cellular-mediated response.