Clinical aspects of obstructive sleep apnea and comorbidities

Olga Chizhova

Clinical aspects of obstructive sleep apnea and comorbidities

Číslo: 1/2017
Periodikum: Medical and Health Science Journal

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Anotace: Introduction: Obstructive sleep apnea (OSA) is associated with adverse health outcomes, particularly, with cardiovascular/metabolic disorders.

Objectives: to evaluate signs of respiratory failure in patients with OSA without evidence of chronic airflow obstruction/restriction and to identify relations between abnormal respiratory pattern and associated cardiovascular and metabolic comorbidities in these patients.
Methods: 360 males with mild, moderate and sever OSA underwent a clinical study with standard full night polysomnography. Breathlessness at baseline was assessed with Baseline Dyspnea Index, pulmonary function test and arterial blood gas analysis. Fasting and 2-hour glucose levels measured during an oral glucose tolerance test were used to assess glycemic status, as well as body mass index and waist-to-hip ratio. ECG and blood pressure monitoring were used to assess cardiovascular system.
Results: Presence of various cardiovascular and metabolic comorbidities in patients with OSA is correlated with intermittent hypoxemia and hypercapnia and can be predicted by the severity of OSA.
Conclusions: The results allow us to suggest that severe abnormal nocturnal pattern of breathing in OSA patients is resulted in respiratory failure even without presence of chronic airflow obstruc-tion/restriction. Presence of various cardiovascular and metabolic comorbidities in patients with OSA is correlated with intermittent hypoxemia and hypercapnia and can be predicted by the severity of OSA.