Aim: The study aim was to establish the differences in the levels of anxiety, depression, and quality of life in patients with acne and atopic dermatitis, to examine differences related to gender, and to examine the relationship of levels of anxiety, depression, and quality of life to age and personality traits. Design: A cross-sectional study. Methods: The Hospital Anxiety and Depression Scale (HADS), the Beck Depression Inventory (BDI), and the Dermatology Life Quality Index (DLQI) were used for data collection, and the Mini International Personality Item Pool (IPIP) was used for identification of five personality factors. Results: No statistically significant differences were found between patients with acne and patients with atopic dermatitis regarding levels of anxiety, depression, and quality of life. In terms of age, a difference was found only in the incidence of anxiety in the group of patients with acne; higher anxiety was found in women. There were no statistically significant differences in anxiety, depression, and quality of life related to age in patients with acne and atopic dermatitis. Significant relationships of the variables to personality traits were found in both groups. Conclusion: Knowing the factors influencing the incidence of mental health problems in patients with acne and atopic dermatitis helps in early nursing diagnosis of such problems, which can eliminate the negative impact of mental health problems on patients' quality of life.