Assessment of camel milk yogurt as a cogent approach on streptozotocin (stz) induced diabetes mellitus in sprague - dawley rats

Adnan Khaliq, Tahir Zahoor, Muhammad Nadeem, Muhammad Imran, Syed Amir Gilani, Muhammad Farhan Jahangir Chughtai, Muhammad Bilal Irshad, Atif Liaqat, Imran Pasha, Samreen Ahsan, Faiz-ul-Hassan Shah, Mohammad Ali Shariati, Zhanibek Yessimbekov

Assessment of camel milk yogurt as a cogent approach on streptozotocin (stz) induced diabetes mellitus in sprague - dawley rats

Číslo: 3/2019/2020
Periodikum: Journal of Microbiology, Biotechnology and Food Sciences
DOI: 10.15414/jmbfs.2019/20.9.3.648-652

Klíčová slova: Diabetes, camel milk, Insulin increment, improved clinical symptoms, minimal determental effects

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Anotace: According to Global report of World Health Organization (WHO) on diabetes, a predictable frequency of diabetes in the grown-up

populace has nearly elevated 2-fold since 1980 from 4.7% to 8.5%. Altogether, mainstream of individuals is suffering from Type 1
diabetes mellitus of all diabetes cases which is a serious metabolic disorder and frightening state of cases booming annually. Camel
milk, fresh/ fermented has the properties to be acknowledging for its potential effect for the cure of diabetes mellitus type 1. The higher
concentration of insulin/insulin mimics particles in camel milk, like half cysteine, small sized immunoglobulins and their optimistic
impact on beta cells and resistance to coagulation in acidic environment of stomach contributes to hypoglycemic effect in type 1
diabetes. The persistence of this study was the evaluation of camel milk yogurt on experimental Sprague-Dawley rats for type 1
diabetes. Two types of studies were conducted with four groups depending upon the diet. The analysis of serum glucose, insulin levels,
liver and kidney functioning tests, and hematological analysis were performed to access the therapeutic potential of camel milk yogurt
during efficacy trials. Serum glucose and insulin results showed that camel milk yogurt exhibited 3.69 % reduction of serum glucose
level in study-I (fed on cow milk yogurt) whereas, 13.88% reduction was reported in study-II (fed on camel milk yogurt). Insulin
concentration was increased 1.84 % in study-I whereas, 15.22 % was increased in study-II. Categorically, insulin percentage increment
enlightened that induction of camel milk yogurt to subjects revealed better results in comparison to cow milk yogurt. The protective
perspectives of camel milk yogurt supplementation to rats did not impart any deleterious effect on biochemical markers of the rats.
Overall research showed that camel milk yogurt administration improved the clinical symptoms of diabatic rats along with minimal
determental effects on health stratum of rats group.