Ulugbek G. Gayibov
Influence of new polyphenol compound from euphorbia plant on mitochondrial function
Periodikum: Journal of Microbiology, Biotechnology and Food Sciences
Klíčová slova: mitochondria, mPTP, mitoKATP, antioxidant activity, polyphenol compounds, hypoxia
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Anotace: In this article we investigate influence of new polyphenol compound 1-О-galloyl-6-О-bisgalloyl-2,4-valenoyl-β-D-glucose, extracted from Euphorbia Himufuza (Wild.) plant, on functional parameters of mitochondria. It was shown that above mentioned new polyphenol compound has a positive effect to some functional parameters of mitochondria. For example, this compound inhibits the mitochondrial permeability transition pore (mPTP) opening, activates ATP-dependant potassium channel and has high antioxidant/antiradical activity. Improving of functional characteristics of mitochondria by polyphenol compounds, served as the basis for the hypothesis of a possible antihypoxic effect of 1-О-galloyl-6-О-bisgalloyl-2,4-valenoyl-β-D-glucose due to its low toxicity.