In vitro antischistosomal activity of allium cepa l. (red onion) extracts and identification of the essential oil composition by gc-ms

Ezzat Abdel-Lateef, Ibrahim Rabia, Mahfouz Abdel-Gawad, Mortada El-Sayed

In vitro antischistosomal activity of allium cepa l. (red onion) extracts and identification of the essential oil composition by gc-ms

Číslo: 4/2017/2018
Periodikum: Journal of Microbiology, Biotechnology and Food Sciences
DOI: 10.15414/jmbfs.2018.7.4.421-425

Klíčová slova: Allium cepa L., antischistosomal activity, GC-MS analysis

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Anotace: Allium cepa L. (red onion) is one of the most famous vegetable crops grown in Egypt due to its medical and nutritional importance. In vitro antischistosomal bioassay of ethyl acetate (EtOAc) and butanolic (BuOH) fractions derived from methanolic (MeOH) extract of A. cepa as well as the essential oil of plant bulbs was carried out using ascending doses. The chemical constituents of essential oil were further investigated using GC-MS analysis. The results revealed that the MeOH extract, EtOAc fraction, BuOH fraction and essential oil have a significant effect on adult Schistosoma mansoni worms. The essential oil of A. cepa gave high worm mortality (%) at the concentration 500 µg/mL (75%), 250 µg/mL (50%) and 125 µg/mL (30%) death rate after 24 hours. GC-MS analysis of A. cepa essential oil exhibited different chemical volatile constituents such as organosulfur compounds, alcohols, acids, esters, furans, phenols, and aldehyde. 3, 5-Diethyl -1, 2, 4-trithiolane (10.17%), 1, 3, 5-trithiolane (7.80%), and 3-(2H-furanone, 2-hexyl-5-methyl) (7.74%) represented the highest contents percent in essential oil of A. cepa bulbs.Zobrazit více »